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Heartburn Sufferers Look To PPI Drugs To Control Acid Reflux Disease and GERD

Without ranitidine (Zantac) consumers have switched to PPI drugs for relief

Monday, February 1, 2021 - Searching Google for the term heartburn drugs no longer yields ranitidine drugs like Zantac, once the world's best-selling heartburn and acid reflux medicine. On April 1, 2020, the Food and Drug Administration (FDA) recalled and banned the sale of all types of ranitidine including the popular Zantac over fears that the drug contained carcinogenic levels of the carcinogen NDMA. NDMA is a byproduct of rocket fuel and was used by scientists to induce tumors in cancer test animals. NDMA is banned in the US. Instead, the search results from Google default to a class of ant-acids labeled protein pump inhibitors (PPI). The FDA has tested and found PPI drugs to be safe from the carcinogenic quantities of NDMA that the agency found in Zantac and other H2 antagonist drugs. WebMD lists the following as acceptable drugs to treat general acid indigestion. "Proton Pump Inhibitors (PPIs) for Heartburn and Reflux... Dexlansoprazole (Dexilant), Esomeprazole (Nexium), Lansoprazole (Prevacid), Omeprazole (Prilosec, Zegerid), Pantoprazole (Protonix), and Rabeprazole (Aciphex)." While making lifestyle changes is often the best solution to combat acid reflux, heartburn, or gastrointestinal disease (GERD), one should not leave these conditions untreated. One should consider supplementing their lifestyle upgrade with an FDA-approved PPI.

PPI drugs are different from H2 antagonist drugs like Zantac in several important ways. The most significant I think is that a PPI drug is taken regularly prophylactically in anticipation of heartburn and acid reflux symptoms where a Zantac (ranitidine) is taken when needed. According to Harvard University, "PPIs work by inhibiting certain stomach cells from "pumping" acid into the stomach. When taken 30 to 60 minutes before a meal, PPIs can prevent or reduce heartburn. However, they do not work as well when taken on-demand as they do when taken over time." Zantac is an H2 receptor blocker that interferes with stomach acid production. "H2 blockers are a group of medicines that reduce the amount of acid produced by the cells in the lining of the stomach. They are also called 'histamine H2-receptor antagonists' but are commonly called H2 blockers," according to Digestive Health. According to the FDA, PPI drugs now offer a safe alternative to ranitidine (Zantac).

Over 500 lawsuits and potentially thousands more are waiting to be filed, from individuals that have developed cancer of the stomach, bladder, and others allegedly from taking Zantac regularly and for many years. Individuals should speak with a Zantac Cancer Lawyer to find out if they qualify to file a claim against Sanofi, the maker of Zantac. Sanofi is under criminal investigation for allegedly lying to government regulators, doctors, and consumers about what they knew or could be expected to know about NDMA in Zantac. Government agencies and independent scientists have spent the last year studying the relationship between ranitidine and NDMA increases, and have generally concluded that ranitidine is inherently unstable. That does not explain, however, how certain blood pressure medicines and also metformin have developed dangerously elevated levels of NDMA also.

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OnderLaw, LLC is a St. Louis personal injury law firm handling serious injury and death claims across the country. Its mission is the pursuit of justice, no matter how complex the case or strenuous the effort. The Onder Law Firm has represented clients throughout the United States in pharmaceutical and medical device litigation such as Pradaxa, Lexapro and Yasmin/Yaz, where the firm's attorneys held significant leadership roles in the litigation, as well as Actos, DePuy, Risperdal and others. The Onder Law Firm has won more than $300 million in four talcum powder ovarian cancer lawsuits in St. Louis. Law firms throughout the nation often seek its experience and expertise on complex litigation.

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